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  • 姓名:
  • 陈陆馗
  • 职称:
  • 副教授、硕导
  • 科室:
  • 大外科
  • 单位:
  • 厦门大学附属中山医院

     陈陆馗,男,医学博士,博士后。东南大学附属中大医院神经外科主任,主

    任医师,研究生导师。东南大学引进学科带头人,留美、留日归国专家。
    现任ACNS(亚洲神经外科医师协会)教育委员会委员。国际著名期刊《Stroke》和《Clinical Neurology and Neurosurgery》等的特邀审稿专家。
        专业技术特长:具有丰富的神经外科临床经验及手术技能,在锁孔微创技术方面居于国际领先水平。擅长显微手术治疗胶质瘤、脑膜瘤、垂体腺瘤、颅咽管瘤、听神经瘤、脑室内肿瘤、下丘脑错构瘤、脑干肿瘤、颅底肿瘤、颅颈交界区肿瘤、脊髓肿瘤、颅内动脉瘤、脑血管畸形、海绵状血管瘤、烟雾病、面肌痉挛、三叉神经痛、环枕畸形、顽固性癫痫、帕金森病等。特别擅长锁孔内镜下手术、颅内外动脉搭桥重建术,在脑血管病的微创外科治疗方面具有很深的造诣。
    在国内外专业杂志发表50余篇论文。SCI收录15篇,其中第一作者11篇。对恶性胶质瘤、垂体腺瘤和神经干细胞移植有深入的研究。
        专家门诊时间:周三上午

    专业擅长:

          具有全面的神经外科理论知识和丰富的临床经验及实践技能。在常规开展显微手术治疗各类颅脑肿瘤、脊髓肿瘤、颅内动脉瘤、脑血管畸形、烟雾病、三叉神经痛和面肌痉挛等的基础上,先后开展了神经导航精确定位颅内病灶切除术、锁孔微创颅内动脉瘤夹闭术和颅底肿瘤切除术、神经内镜下经单鼻孔蝶窦鞍区肿瘤切除术、术中皮层电极监测癫痫病灶切除术、血管内介入技术诊断和治疗各部位颅内动脉瘤及血管畸形等,病人的治疗效果满意。

    临床试验:

    Trial for effects of aspirin plus clopidogrel on prevention of recurrent ischemic stroke due to intracranial artery stenosis
     
     
    First Received on July 2, 2005.   Last Updated on July 25, 2010
     
     
    Sponsor:
    Zhongshan Hospital, Xiamen University
    Collaborator:
    Railway Clinical Hospital, Irkutsk; Keio University Hospital, Tokyo
    Information provided by:
    Zhongshan Hospital, Xiamen University
    Identifier:
    ZS20050702 (Zhongshan Hospital, Xiamen University)
    Principal Investigator:
    Lukui Chen, MD, PhD
     
     
    Purpose
     
    This study will recruit over 200 acute stroke (including TIA) patients with symptomatic intracranial stenosis.
     
    They will be randomly assigned into three groups (Group A: aspirin; Group C: clopidogrel; Group D: aspirin plus clopidogrel).
     
    The primary outcome variable of this study is recurrent ischemic stroke, mean survival time, brain hemorrhage, or death from vascular causes other than stroke.
     
     
     


    Study Type:
    Interventional
    Study Design:
    Allocation: Randomized
    Endpoint Classification: Efficacy Study
    Intervention Model: Parallel Assignment
    Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
    Primary Purpose: Treatment
    Official Title:
    Trial for effects of aspirin plus clopidogrel on prevention of recurrent ischemic stroke due to intracranial artery stenosis

     
     
    Eligibility

    Ages Eligible for Study:  
    40 Years and older
    Genders Eligible for Study:  
    Both
    Accepts Healthy Volunteers:  
    No

     
    Criteria
     
    Inclusion Criteria:
    · At least 40 years of age
    · Modified Rankin Scale of 3 or less
    · Initial nondisabling ischemic stroke including transient ischemic attack (TIA) that was attributable to angiographically verified 50 to 99 percent stenosis or complete occlusion of a major intracranial artery (carotid, middle cerebral, vertebral, or basilar).
    Exclusion Criteria:
    · Nonatherosclerotic stenosis of an intracranial artery
    · Cardiac source of embolism
    · Contraindication to aspirin or clopidogrel therapy
    · Coexisting condition that limited survival to less than five years
     
     
     
    Detailed Description:
     
    [Purpose] To Reveal the effects of aspirin plus clopidogrel on prevention of recurrent ischemic stroke due to intracranial artery stenosis comparing to aspirin alone.
     
    [Trial Design] Double-Blind, Active-Controlled, Randomized, Multicenter Trial
     
    [Participants] Acute ischemic stroke patients with symptomatic intracranial arterial stenosis.
     
    [Methods] The initially prescribed dose of enteric-coated aspirin is 100 mg daily, and that of clopidogrel is 75 mg daily. Aspirin could be replaced by clopidogrel if side effects, such as dyspepsia, develop.
    Patients are contacted monthly to determine whether any events occur. Every four months, patients are examined by a blinded investigator who also managed the patient’s vascular risk factors. The components of the primary end points (ischemic stroke, brain hemorrhage, or death from vascular causes other than stroke) are adjudicated by independent panels of neurologists and cardiologists who were unaware of the patients’ study group assignments. All patients are to be followed until any single component of the primary end points or death occur or a common termination date (expected to be 7 months after the last patient is enrolled) is reached.
     


    SCI英文汇总

    1. Lukui Chen(陈陆馗), William L. White, et al. A Prospective Study of Nonfunctioning Pituitary Adenomas: presentation, management, and clinical outcome. Journal of Neuro-Oncology. 2011; 102(1): 129-138
    2. Lukui Chen(陈陆馗), William L. White, et al. Transnasal Transsphenoid Approach: a minimally invasive approach for removal of cavernous hemangiomas located at inferomedial part of orbital apex. Clin Experiment Ophthalmol. 2010; 38(5): 439-43
    3. Lukui Chen(陈陆馗), Robert F. Spetzler, et al. Detection of Ischemia in Endovascular Therapy of Cerebral Aneurysms: A Perspective in the Era of Neurophysiological Monitoring. Neurosurgical Review. 2011; 34(1): 69-75
    4. Lukui Chen(陈陆馗), Yoko Kato, KL Karagiozov, et al. Usefulness of A Simplified Management Scheme for Paraclinoid Aneurysms: based on a modified classification. Cerebrovasc Dis. 2008, 26: 388-396
    5. Lukui Chen(陈陆馗), Yoko Kato, Hirotoshi Sano, et al. Management of Complex, Surgically Intractable Intracranial Aneurysms: The Option for Intentional Reconstruction of Aneurysm Neck Followed by Endovascular Coiling. Cerebrovasc Dis. 2007; 23(5-6):381-387
    6.  Lukui Chen(陈陆馗), Abhishek Agrawal, Yoko Kato, et al. Aneurysm Projection and A2 Fork Orientation: determinants for side of surgical approach to Anterior Communicating Artery Aneurysms. Acta Neurochir. 2009, 151(8):925-933
    7.  Lukui Chen(陈陆馗), Xinhua Tian, Junqing Zhang, et al. Eyebrow Keyhole Approach for Ruptured Anterior Circulation Aneurysms on Early Stage. Acta Neurochir. 2009,151(7): 781-784
    8.  Lukui Chen(陈陆馗), Yunsheng Liu, Yonghong Hou, et al. Expression and Structure of Interleukin 4 Receptor (IL-4R) Complex in Human Invasive Pituitary Adenomas. Neurosci Lett. 2007; 417(1):30-35.
    9.  Lukui Chen(陈陆馗), Xinhua Tian, Wenzhu Li, et al. Expressions of Fas/DcR3 and RGD-FasL mediated apoptosis in pituitary adenomas. Neurology India 2009, 57(1):28-30
    10. Lukui Chen(陈陆馗), Guohong Zhuang, Wenzhu Li, et al. RGD-FasL Induces Apoptosis of Pituitary Adenoma Cells. Cell Mol Immunol. 2008;5(1):61-68
    11. Agrawal A, Kato Y, Chen L(陈陆馗), et al. Anterior communicating artery aneurysms: an overview. Minim Invasive Neurosurg. 2008;51(3):131-5.
    12. Kumar MV, Karagiozov KL, Chen L(陈陆馗), et al. A classification of unruptured middle cerebral artery bifurcation aneurysms that can help in choice of clipping technique. Minim Invasive Neurosurg. 2007;50(3):132-9.
    13. Diao Y, Tian XH, Huang YL, Chen LK(陈陆馗), Lin XN, Zhuang ZW. Enhanced Cancer Therapy with the Combination of EGFR and VEGFR-2 Targeting in an Orthotopic Glioblastoma Model. J Chemother, 2011, 22(6):407-412.
    14. Yi D, Hua TX, Lin HY, Kui CL(陈陆馗), Ning LX, Wang ZZ. Antitumor treatment efficacy by targeting epidermal growth factor receptor and vascular endothelial growth factor receptor-2 in an orthotopic human glioblastoma model. J Neurooncol, 2010 Dec 8. [Epub ahead of print]
    15. Yoko Kato, Lukui Chen(陈陆馗), Hirotoshi Sano, et al. Combined microsurgical and endovascular modalities for complex intracranial aneurysms. Ningen Dock. 2007; 21(6):5-10
    16. V.A. Byvaltsev, Yoshio Suzuki, Nobuo Hashimoto, V.A. Sorokovikov, Lukui Chen(陈陆馗). Moyamoya Disease. Surgery of Ukraine. 05 Sep. 2008

     

     
    陈陆馗-科主任,主任医师,学科带头人,留学归国专家
    简历:
        陈陆馗,男,医学博士,博士后。东南大学附属中大医院神经外科主任,主
    任医师,研究生导师。东南大学引进学科带头人,留美、留日归国专家。
    现任ACNS(亚洲神经外科医师协会)教育委员会委员。国际著名期刊《Stroke》和《Clinical Neurology and Neurosurgery》等的特邀审稿专家。
        专业技术特长:具有丰富的神经外科临床经验及手术技能,在锁孔微创技术方面居于国际领先水平。擅长显微手术治疗胶质瘤、脑膜瘤、垂体腺瘤、颅咽管瘤、听神经瘤、脑室内肿瘤、下丘脑错构瘤、脑干肿瘤、颅底肿瘤、颅颈交界区肿瘤、脊髓肿瘤、颅内动脉瘤、脑血管畸形、海绵状血管瘤、烟雾病、面肌痉挛、三叉神经痛、环枕畸形、顽固性癫痫、帕金森病等。特别擅长锁孔内镜下手术、颅内外动脉搭桥重建术,在脑血管病的微创外科治疗方面具有很深的造诣。
    在国内外专业杂志发表50余篇论文。SCI收录15篇,其中第一作者11篇。对恶性胶质瘤、垂体腺瘤和神经干细胞移植有深入的研究。
        专家门诊时间:周三上午


     

发布时间:2010年07月02日
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